Study of Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Congenital Heart Disease

Hajer Ali Al Mesmari; Tarek Mustafa El Walili; Akram Abdel Moneim Deghady; Rania Mohamed Abdelsadek Elhaddad

doi:https://doi.org/10.63720/v1i2004

Study of Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Congenital Heart Disease

Hajer Ali Al Mesmari (Corresponding Author), Tarek Mustafa El Walili, Akram Abdel Moneim Deghady, Rania Mohamed Abdelsadek Elhaddad

Journal of The Best Available Evidence in Medicine Volume 1, Issue 2 Pages 2017-0099 Published: 2025-11-11 DOI: https://doi.org/10.63720/v1i2004

Abstract

IGFBP-3, are crucial mediators of childhood growth and development. Alterations in their serum levels have been implicated in congenital heart disease (CHD), especially in relation to chronic hypoxia and growth failure. Aim: To evaluate serum IGF-1 and IGFBP-3 levels in children with CHD, to compare variations between cyanotic and acyanotic subtypes, and to explore correlations with anthropometric and clinical parameters.

Keywords

Congenital Heart Disease, Cyanosis, IGF-1, IGFBP-3, Growth Failure, Hypoxia, Paediatric Biomarkers