Aspirin’s Expanding Role in Cardiovascular Health, Inflammation Control, and Cancer Prevention

To the Editor, We read with great interest the article by Yang et al., titled “Aspirin prevents metastasis by limiting platelet TXA₂ suppression of T cell immunity,” highlighting aspirin’s potential in reducing cancer metastasis.1 The suppression of TXA₂-mediated activation of the ARHGEF1 protein is critical in T cell receptor signaling. Such signaling suppression compromises T cell activation and immune surveillance, and facilitates cancer cell metastasis. By blocking TXA₂ production, aspirin reinstates effective T cell immune responses, thereby significantly decreasing metastatic potential.